MTTP

Across TCGA pan-cancer cohorts, MTTP mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated MTTP data layer compared with 25 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher MTTP mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated MTTP expression acts as an unfavorable survival marker, although some lineages such as COAD and CCRCC show a favorable association.

COAD, CCRCC, and PDAC are the cancer types where MTTP mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	1.000	0.924	.045	12	view →
CCRCC	OS	Median	All	0.982	0.904	.026	11	view →
PDAC	DFS	Median	IV	0.934	0.250	.024	5	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

MTTP–COAD (DFS)

Open the COAD breakdown →