MTTP

Across TCGA patient cohorts, MTTP protein abundance is significantly associated with the RNA expression of many other genes, with 9,336 significant associations in total. GBM shows the largest number of these associations.

The most reproducible MTTP-associated genes across cancer lineages are PPM1L, SLC5A9, and PRAP1. Each is linked with MTTP in more than 2 cancer types. Because this analysis shows association rather than direction, both MTTP-to-partner and partner-to-MTTP results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MTTP versus PPM1L in LSCC, with a Pearson correlation of -0.45.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTTP→partner) and Y-score (partner→MTTP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PPM1L →	-1.125	-0.982	.001	.009	3	3
COAD	SLC5A9 →	+0.854	+0.963	<.001	.003	3	2
COAD	PRAP1 →	+0.717	+1.019	.002	.001	3	2
PDAC	OR10AE3P →	+0.117	+0.998	.006	.003	3	2
LSCC	TTLL1 →	-0.580	-1.123	.007	.004	3	2
LSCC	SLC25A17 →	-0.375	-0.861	.004	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,336 associations by consensus.

MTTP vs PPM1L — LSCC

Explore this scatter interactively →