MKS transition zone complex subunit 1Genealiases: BBS13 · JBTS28 · MES · MKS · POC12
Q-omics provides the consensus-scored MKS1 profile across patient tissues and cancer cell-line models. MKS1 expression is associated with patient survival in 27 of 34 cancer types, with the highest sampling consensus in LGG. Among the 18 cancer types available for tumor–normal comparison, MKS1 is differentially expressed in 15, with the highest sampling consensus in KICH. Additionally, MKS1 RNA expression shows 19,905 significant gene co-expression associations, with the highest sampling consensus in ACC. Together, these results highlight LGG, KICH, and ACC as cancer lineages where MKS1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for MKS1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes MKS1 survival associations across molecular data types. MKS1 RNA expression shows survival associations in the most cancer types (27), followed by mutation status (5) and mass-spec protein abundance (3). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible MKS1 RNA expression–survival associations across cancer types. High MKS1 expression shows unfavorable associations in LGG, ACC, LIHC and KIRC, but favorable associations in READ and UVM. The LGG Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify LGG as the clearest survival context for MKS1 RNA expression.
This table summarizes MKS1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 15, while mass-spec protein shows differences in 3. The strongest signals are observed in KICH for RNA and LUAD for protein.
This table ranks reproducible tumor–normal expression differences for MKS1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. MKS1 shows lower tumor expression in KICH and THCA and higher tumor expression in COAD, KIRP, LIHC and BLCA. The KICH box plot shows higher MKS1 RNA expression in normal versus tumor tissue (log2 FC = −1.495, t-test p < 0.001).
This table shows molecular features associated with MKS1 in patient tissues and cancer cell lines. In patient samples, MKS1 shows the broadest associations at the RNA and protein expression levels, with ACC recurring as the lineage with the largest associated feature set. In cancer cell lines, MKS1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in UPPER_AERODIGESTIVE_TRACT, while CRISPR and shRNA rows add functional-dependency signals in LUNG_NSCLC_LUAD and BLOOD_Leukemia.
