MKS1

Across TCGA pan-cancer cohorts, MKS1 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated MKS1 data layer compared with 27 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher MKS1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated MKS1 expression acts as an unfavorable survival marker.

LUAD and LSCC are the cancer types where MKS1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	All	0.764	0.944	.002	26	view →
LSCC	DFS	Quartile	All	0.596	0.938	.011	14	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

MKS1–LUAD (DFS)

Open the LUAD breakdown →