MKS1

Across TCGA pan-cancer cohorts, MKS1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of MKS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where MKS1 RNA is repressed in tumor relative to normal tissue. In most cancer types MKS1 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, COAD, and THCA are the cancer types where MKS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MKS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−1.495	<.001	11	view →
COAD	Male	III,IV	+0.809	<.001	10	view →
THCA	Male	III,IV	−0.555	<.001	10	view →
KIRP	All	II,III,IV	+0.836	<.001	9	view →
LIHC	Female	II,III,IV	+0.784	<.001	9	view →
BLCA	All	All	+0.706	<.001	8	view →
STAD	All	II,III,IV	+0.653	<.001	8	view →
HNSC	Male	III,IV	+0.546	<.001	8	view →
LUSC	All	All	+0.578	<.001	6	view →
LUAD	All	III,IV	+0.521	<.001	6	view →
BRCA	All	II,III,IV	+0.262	.005	6	view →
CHOL	Male	All	+2.348	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

MKS1–KICH

Open the KICH breakdown →