MKS1

Across TCGA pan-cancer cohorts, MKS1 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated MKS1 data layer compared with 5 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in brain lower grade glioma (LGG), where higher MKS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MKS1 expression acts as an unfavorable survival marker, although some lineages such as READ and UVM show a favorable association.

LGG, READ, and ACC are the cancer types where MKS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	DFS	Median	All	0.332	0.462	<.001	46	view →
READ	DFS	Quartile	II,III,IV	0.931	0.217	.001	46	view →
ACC	OS	Median	IV	0.307	0.734	.002	41	view →
LIHC	DFS	Tertile	All	0.405	0.585	<.001	35	view →
UVM	DFS	Quartile	All	0.859	0.440	.012	24	view →
KIRC	DFS	Tertile	II,III,IV	0.434	0.643	.008	23	view →
COAD	DFS	Median	IV	0.252	0.725	.002	21	view →
BRCA	DFS	Tertile	All	0.968	0.931	.021	17	view →
BLCA	DFS	Median	III,IV	0.484	0.603	.009	16	view →
LUAD	OS	Tertile	II,III,IV	0.791	0.611	.007	15	view →
UCEC	DFS	Median	All	0.920	0.873	.011	12	view →
MESO	DFS	Quartile	III,IV	0.122	0.524	.010	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

MKS1–LGG (DFS)

Open the LGG breakdown →