MKS1

Across TCGA cell cohorts, MKS1 mutation is significantly associated with the RNA expression of many other genes, with 1 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MKS1-associated genes across cancer lineages are MCHR2. Each is linked with MKS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MKS1-to-partner and partner-to-MKS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MCHR2 grouped by MKS1-low versus MKS1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MKS1→partner) and Y-score (partner→MKS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MCHR2 →	+0.026	+3.684	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 1 strongest of 1 associations by consensus.

MCHR2 by MKS1 expression — LARGE_INTESTINE

Explore this box plot interactively →