MKS1

Across TCGA pan-cancer cohorts, MKS1 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated MKS1 data layer compared with 27 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher MKS1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated MKS1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUSC show a favorable association.

SKCM, CESC, and KICH are the cancer types where MKS1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.285	0.788	<.001	25	view →
CESC	DFS	Median	All	0.172	0.743	<.001	24	view →
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
UCEC	DFS	Median	II,III,IV	0.922	0.439	.033	6	view →
LUSC	OS	Median	All	1.000	0.384	.045	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

MKS1–SKCM (OS)

Open the SKCM breakdown →