mannosidase alpha class 2B member 2Genealiases: CDG1EE · EpMAN
Q-omics provides the consensus-scored MAN2B2 profile across patient tissues and cancer cell-line models. MAN2B2 expression is associated with patient survival in 23 of 34 cancer types, with the highest sampling consensus in KICH. Among the 18 cancer types available for tumor–normal comparison, MAN2B2 is differentially expressed in 9, with the highest sampling consensus in HNSC. Additionally, MAN2B2 protein abundance shows 21,712 significant protein co-abundance associations, with the highest sampling consensus in BRCA. Together, these results highlight KICH, HNSC, and BRCA as cancer lineages where MAN2B2 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for MAN2B2 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes MAN2B2 survival associations across molecular data types. MAN2B2 RNA expression shows survival associations in the most cancer types (23), followed by mutation status (9) and mass-spec protein abundance (9). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible MAN2B2 RNA expression–survival associations across cancer types. High MAN2B2 expression shows unfavorable associations in KICH, LGG and LUSC, but favorable associations in UCEC, PAAD and PRAD. The KICH Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KICH as the clearest survival context for MAN2B2 RNA expression.
This table summarizes MAN2B2 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 9, while mass-spec protein shows differences in 7. The strongest signals are observed in HNSC for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for MAN2B2. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. MAN2B2 shows lower tumor expression in THCA, KICH and LUSC and higher tumor expression in HNSC, STAD and LIHC. The HNSC box plot shows higher MAN2B2 RNA expression in tumor versus normal tissue (log2 FC = +0.880, t-test p < 0.001).
This table shows molecular features associated with MAN2B2 in patient tissues and cancer cell lines. In patient samples, MAN2B2 shows the broadest associations at the RNA and protein expression levels, with BRCA recurring as the lineage with the largest associated feature set. In cancer cell lines, MAN2B2 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LUNG_NSCLC_LUAD, while CRISPR and shRNA rows add functional-dependency signals in LARGE_INTESTINE and UPPER_AERODIGESTIVE_TRACT.
