MAN2B2

Across TCGA patient cohorts, MAN2B2 mutation is significantly associated with the RNA expression of many other genes, with 3,420 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAN2B2-associated genes across cancer lineages are RNU5E-9P, FMO10P, and DUX4L19. Each is linked with MAN2B2 in more than 3 cancer types. Because this analysis shows association rather than direction, both MAN2B2-to-partner and partner-to-MAN2B2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU5E-9P grouped by MAN2B2-low versus MAN2B2-high in LGG.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAN2B2→partner) and Y-score (partner→MAN2B2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LGG	RNU5E-9P →	+0.362	+4.447	<.001	.007	3	3
LGG	FMO10P →	+0.040	+3.650	<.001	.009	3	3
LGG	DUX4L19 →	+0.028	+4.906	<.001	.004	3	3
LIHC	RNU6-1198P →	+0.608	+4.758	<.001	.006	3	3
SKCM	ELOCP5 →	+0.019	+3.903	<.001	.007	3	3
SKCM	MIR4692 →	+0.120	+2.858	.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,420 associations by consensus.

RNU5E-9P by MAN2B2 expression — LGG

Explore this box plot interactively →