MAN2B2

Across TCGA pan-cancer cohorts, MAN2B2 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated MAN2B2 data layer compared with 9 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher MAN2B2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated MAN2B2 expression acts as an unfavorable survival marker, although some lineages such as PAAD and UCEC show a favorable association.

KICH, LGG, and PAAD are the cancer types where MAN2B2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	OS	Tertile	II,III,IV	0.503	1.000	<.001	55	view →
LGG	OS	Median	All	0.381	0.509	<.001	49	view →
PAAD	OS	Median	All	0.726	0.441	<.001	30	view →
UCEC	DFS	Quartile	II,III,IV	0.895	0.729	.005	30	view →
LUSC	DFS	Tertile	II,III,IV	0.234	0.548	.008	24	view →
PRAD	DFS	Quartile	All	0.900	0.698	.001	18	view →
SKCM	DFS	Quartile	II,III,IV	0.353	0.173	.002	17	view →
SCLC	DFS	Quartile	All	0.789	0.395	.002	17	view →
KIRC	DFS	Median	All	0.720	0.541	.013	16	view →
ACC	DFS	Median	IV	0.472	0.089	.012	14	view →
MESO	DFS	Quartile	III,IV	0.113	0.622	.017	12	view →
THYM	DFS	Quartile	All	1.000	0.590	.016	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

MAN2B2–KICH (OS)

Open the KICH breakdown →