MAN2B2

Across TCGA pan-cancer cohorts, MAN2B2 Mutation is linked to patient survival in 9 of 34 cancer types, making it a survival-associated MAN2B2 data layer compared with 23 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher MAN2B2 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated MAN2B2 expression acts as an unfavorable survival marker, although some lineages such as STAD and UCEC show a favorable association.

HNSC, BRCA, and SKCM are the cancer types where MAN2B2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	III,IV	0.013	0.746	<.001	24	view →
BRCA	OS	Median	III,IV	0.165	0.833	<.001	20	view →
SKCM	OS	Median	IV	0.179	0.755	<.001	17	view →
STAD	OS	Median	All	0.964	0.675	.019	10	view →
SCLC	OS	Median	All	0.082	0.822	<.001	9	view →
THYM	DFS	Median	All	0.134	0.871	<.001	6	view →
UCEC	DFS	Median	All	0.913	0.619	.044	4	view →
LIHC	OS	Median	II,III,IV	0.239	0.715	.035	3	view →
KIRP	OS	Median	All	0.192	0.704	.036	2	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

MAN2B2–HNSC (OS)

Open the HNSC breakdown →