MAN2B2

Across TCGA patient cohorts, MAN2B2 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. COAD shows the largest number of these associations.

The most reproducible MAN2B2-associated genes across cancer lineages are INPP4B, Lck, and E-Cadherin. Each is linked with MAN2B2 in more than 2 cancer types. Because this analysis shows association rather than direction, both MAN2B2-to-partner and partner-to-MAN2B2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by MAN2B2-low versus MAN2B2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAN2B2→partner) and Y-score (partner→MAN2B2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	INPP4B →	-0.330	-3.000	.024	.034	3	3
COAD	Lck →	+0.242	+2.141	.044	.010	3	3
COAD	E-Cadherin →	-0.489	-3.000	.049	.035	3	3
UCEC	Rad50 →	-0.195	-1.362	.023	.037	3	3
COAD	EGFR_pY1068 →	-0.340	-3.309	.008	.009	3	2
COAD	PKC-b-II_pS660 →	-0.336	-3.169	.015	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

INPP4B by MAN2B2 expression — COAD

Explore this box plot interactively →