MAN2B2

Across TCGA patient cohorts, MAN2B2 protein abundance is significantly associated with the RNA expression of many other genes, with 11,830 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible MAN2B2-associated genes across cancer lineages are SAMD1, TLL1, and POLE2. Each is linked with MAN2B2 in more than 4 cancer types. Because this analysis shows association rather than direction, both MAN2B2-to-partner and partner-to-MAN2B2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MAN2B2 versus SAMD1 in LSCC, with a Pearson correlation of -0.34.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAN2B2→partner) and Y-score (partner→MAN2B2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SAMD1 →	-0.612	-0.336	<.001	<.001	3	5
HNSC	TLL1 →	+1.001	+0.189	<.001	.005	3	5
LUAD	POLE2 →	-0.712	-0.261	.002	.003	3	4
BRCA	FAM83D →	-1.121	-0.418	<.001	<.001	3	4
BRCA	NUDT1 →	-0.595	-0.461	<.001	<.001	3	4
LUAD	HROB →	-0.774	-0.238	<.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,830 associations by consensus.

MAN2B2 vs SAMD1 — LSCC

Explore this scatter interactively →