MAN2B2

Across TCGA cell cohorts, MAN2B2 mutation is significantly associated with the RNA expression of many other genes, with 1,197 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MAN2B2-associated genes across cancer lineages are LYZL1, MC3R, and FAM25C. Each is linked with MAN2B2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAN2B2-to-partner and partner-to-MAN2B2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LYZL1 grouped by MAN2B2-low versus MAN2B2-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAN2B2→partner) and Y-score (partner→MAN2B2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	LYZL1 →	+0.026	+4.643	<.001	.008	3	2
LUNG_NSCLC_LUAD	MC3R →	+0.051	+3.544	<.001	.009	3	2
BLOOD_Lymphoma	FAM25C →	+0.351	+5.209	<.001	.005	3	2
LARGE_INTESTINE	TWNK →	+0.462	+2.158	<.001	.004	3	2
LARGE_INTESTINE	LZIC →	+0.553	+2.850	<.001	<.001	3	2
LARGE_INTESTINE	NAA38 →	+0.848	+3.321	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,197 associations by consensus.

LYZL1 by MAN2B2 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →