mannosidase alpha class 2B member 1Genealiases: LAMAN · MANB
Q-omics provides the consensus-scored MAN2B1 profile across patient tissues and cancer cell-line models. MAN2B1 expression is associated with patient survival in 23 of 34 cancer types, with the highest sampling consensus in HNSC. Among the 18 cancer types available for tumor–normal comparison, MAN2B1 is differentially expressed in 16, with the highest sampling consensus in KIRC. Additionally, MAN2B1 protein abundance shows 29,952 significant protein co-abundance associations, with the highest sampling consensus in GBM. Together, these results highlight HNSC, KIRC, and GBM as cancer lineages where MAN2B1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for MAN2B1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes MAN2B1 survival associations across molecular data types. MAN2B1 RNA expression shows survival associations in the most cancer types (23), followed by mutation status (3) and mass-spec protein abundance (10). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible MAN2B1 RNA expression–survival associations across cancer types. High MAN2B1 expression shows unfavorable associations in LGG, ACC and KIRP, but favorable associations in HNSC, SCLC and UCEC. The HNSC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify HNSC as the clearest survival context for MAN2B1 RNA expression.
This table summarizes MAN2B1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 16, while mass-spec protein shows differences in 9. The strongest signals are observed in KIRC for RNA and LUAD for protein.
This table ranks reproducible tumor–normal expression differences for MAN2B1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. MAN2B1 shows higher tumor expression in KIRC, HNSC, KIRP, LIHC, STAD and UCEC. The KIRC box plot shows higher MAN2B1 RNA expression in tumor versus normal tissue (log2 FC = +1.240, t-test p < 0.001).
This table shows molecular features associated with MAN2B1 in patient tissues and cancer cell lines. In patient samples, MAN2B1 shows the broadest associations at the RNA and protein expression levels, with GBM recurring as the lineage with the largest associated feature set. In cancer cell lines, MAN2B1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in CNS, while CRISPR and shRNA rows add functional-dependency signals in BLOOD_Leukemia.
