MAN2B1

Across TCGA pan-cancer cohorts, MAN2B1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated MAN2B1 data layer compared with 3 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher MAN2B1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated MAN2B1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SCLC show a favorable association.

HNSC, LGG, and SCLC are the cancer types where MAN2B1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	III,IV	0.370	0.167	<.001	80	view →
LGG	OS	Median	All	0.352	0.542	<.001	52	view →
SCLC	OS	Quartile	All	0.656	0.225	.001	49	view →
ACC	DFS	Tertile	All	0.152	0.613	<.001	49	view →
KIRP	DFS	Quartile	All	0.813	0.967	<.001	44	view →
UCEC	DFS	Tertile	III,IV	0.841	0.708	.007	26	view →
UCS	OS	Tertile	IV	0.761	0.141	.024	24	view →
COAD	DFS	Median	All	0.435	0.598	.017	23	view →
PAAD	OS	Median	II,III,IV	0.668	0.502	.007	22	view →
LUAD	DFS	Median	All	0.720	0.611	.005	20	view →
THCA	DFS	Tertile	II,III,IV	0.895	0.982	.008	19	view →
LUSC	DFS	Median	III,IV	0.435	0.996	.003	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

MAN2B1–HNSC (DFS)

Open the HNSC breakdown →