MAN2B1

Across TCGA pan-cancer cohorts, MAN2B1 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of MAN2B1’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where MAN2B1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types MAN2B1 is over-expressed in tumor, although a few such as COAD and CCRCC show the opposite, repressed pattern.

LUAD, COAD, and HNSC are the cancer types where MAN2B1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MAN2B1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	II,III,IV	+0.436	<.001	9	view →
COAD	Female	III,IV	−0.445	<.001	8	view →
HNSC	All	All	+0.182	<.001	8	view →
PDAC	All	All	+0.292	<.001	6	view →
LSCC	All	All	+0.143	<.001	3	view →
CCRCC	All	All	−0.118	.005	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

MAN2B1–LUAD

Open the LUAD breakdown →