MAN2B1

Across TCGA patient cohorts, MAN2B1 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAN2B1-associated genes across cancer lineages are ATM, Caspase-7-cleavedD198, and MAPK_pT202_Y204. Each is linked with MAN2B1 in more than 2 cancer types. Because this analysis shows association rather than direction, both MAN2B1-to-partner and partner-to-MAN2B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by MAN2B1-low versus MAN2B1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAN2B1→partner) and Y-score (partner→MAN2B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.541	-1.700	<.001	.001	3	3
UCEC	Caspase-7-cleavedD198 →	+0.685	+2.584	<.001	<.001	3	3
STAD	MAPK_pT202_Y204 →	+0.395	+3.000	.047	.036	3	2
STAD	Dvl3 →	-0.187	-3.000	.031	.036	3	2
UCEC	eIF4E →	+0.183	+2.321	.004	<.001	3	2
UCEC	STAT3_pY705 →	-0.307	-1.700	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

ATM by MAN2B1 expression — UCEC

Explore this box plot interactively →