MAN2B1

Across TCGA cell cohorts, MAN2B1 mutation is significantly associated with the RNA expression of many other genes, with 33 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MAN2B1-associated genes across cancer lineages are IFNG, FAM71C, and SCRT2. Each is linked with MAN2B1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAN2B1-to-partner and partner-to-MAN2B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IFNG grouped by MAN2B1-low versus MAN2B1-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAN2B1→partner) and Y-score (partner→MAN2B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	IFNG →	+0.006	+5.087	<.001	.004	3	1
SKIN	FAM71C →	+0.012	+4.095	.008	.009	3	1
SKIN	SCRT2 →	+0.006	+4.095	<.001	.009	3	1
STOMACH	SSX7 →	+0.433	+5.285	<.001	.003	3	1
LUNG_NSCLC_LUAD	TSHB →	+0.064	+4.189	<.001	.002	3	1
LUNG_NSCLC_LUAD	KRT24 →	+0.126	+4.093	.006	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

IFNG by MAN2B1 expression — URINARY_TRACT

Explore this box plot interactively →