LDL receptor related protein associated protein 1Genealiases: A2MRAP · A2RAP · HBP44 · MYP23 · RAP · alpha-2-MRAP
Q-omics provides the consensus-scored LRPAP1 profile across patient tissues and cancer cell-line models. LRPAP1 expression is associated with patient survival in 25 of 34 cancer types, with the highest sampling consensus in KICH. Among the 18 cancer types available for tumor–normal comparison, LRPAP1 is differentially expressed in 10, with the highest sampling consensus in KICH. Additionally, LRPAP1 protein abundance shows 19,700 significant protein co-abundance associations, with the highest sampling consensus in GBM. Together, these results highlight KICH, and GBM as cancer lineages where LRPAP1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for LRPAP1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes LRPAP1 survival associations across molecular data types. LRPAP1 RNA expression shows survival associations in the most cancer types (25), followed by mutation status (2) and mass-spec protein abundance (8). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible LRPAP1 RNA expression–survival associations across cancer types. High LRPAP1 expression shows unfavorable associations in KICH, LUSC, UVM and LGG, but favorable associations in PAAD and KIRC. The KICH Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .001). Together, the overview and detailed table identify KICH as the clearest survival context for LRPAP1 RNA expression.
This table summarizes LRPAP1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 10, while mass-spec protein shows differences in 6. The strongest signals are observed in KICH for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for LRPAP1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. LRPAP1 shows lower tumor expression in KICH, LUAD and LUSC and higher tumor expression in LIHC, HNSC and STAD. The KICH box plot shows higher LRPAP1 RNA expression in normal versus tumor tissue (log2 FC = −0.477, t-test p < 0.001).
This table shows molecular features associated with LRPAP1 in patient tissues and cancer cell lines. In patient samples, LRPAP1 shows the broadest associations at the RNA and protein expression levels, with GBM recurring as the lineage with the largest associated feature set. In cancer cell lines, LRPAP1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LIVER, while CRISPR and shRNA rows add functional-dependency signals in BONE and UPPER_AERODIGESTIVE_TRACT.
