LRPAP1

Across TCGA patient cohorts, LRPAP1 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRPAP1-associated genes across cancer lineages are eEF2, MSH2, and MSH6. Each is linked with LRPAP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRPAP1-to-partner and partner-to-LRPAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by LRPAP1-low versus LRPAP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRPAP1→partner) and Y-score (partner→LRPAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.439	+2.321	.014	.035	3	2
UCEC	MSH2 →	-0.569	-3.312	<.001	.010	2	2
UCEC	MSH6 →	-0.663	-3.159	<.001	.019	3	1
UCEC	p27_pT198 →	+0.134	+2.321	.012	.035	3	1
UCEC	PKC-a →	-0.428	-3.459	.035	.005	3	1
UCEC	eIF4E →	+0.257	+3.459	.015	.005	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

eEF2 by LRPAP1 expression — UCEC

Explore this box plot interactively →