LRPAP1

Across TCGA pan-cancer cohorts, LRPAP1 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of LRPAP1’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where LRPAP1 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types LRPAP1 is over-expressed in tumor, although a few such as CCRCC show the opposite, repressed pattern.

CCRCC, COAD, and LUAD are the cancer types where LRPAP1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LRPAP1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Female	III,IV	−0.507	<.001	11	view →
COAD	Female	III,IV	+0.433	<.001	10	view →
LUAD	Female	III,IV	+0.595	<.001	9	view →
HNSC	Male	III,IV	+0.515	<.001	8	view →
PDAC	Female	All	+0.433	<.001	4	view →
LSCC	All	All	+0.148	.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

LRPAP1–CCRCC

Open the CCRCC breakdown →