LRPAP1

Across TCGA cell cohorts, LRPAP1 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LRPAP1-associated genes across cancer lineages are NLRP13, KRTAP2-4, and KRTAP10-4. Each is linked with LRPAP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRPAP1-to-partner and partner-to-LRPAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NLRP13 grouped by LRPAP1-low versus LRPAP1-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRPAP1→partner) and Y-score (partner→LRPAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	NLRP13 →	+0.006	+4.930	<.001	.008	3	1
SOFT_TISSUE	KRTAP2-4 →	+0.122	+4.930	<.001	.008	3	1
SOFT_TISSUE	KRTAP10-4 →	+0.021	+4.930	<.001	.008	3	1
SOFT_TISSUE	PRAMEF18 →	+0.026	+4.930	<.001	.008	3	1
LARGE_INTESTINE	TIFAB →	+0.006	+4.977	<.001	.007	3	1
BLOOD_Leukemia	ASZ1 →	+0.132	+4.152	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

NLRP13 by LRPAP1 expression — SOFT_TISSUE

Explore this box plot interactively →