LRPAP1

Across TCGA patient cohorts, LRPAP1 mutation is significantly associated with the RNA expression of many other genes, with 249 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRPAP1-associated genes across cancer lineages are RNVU1-28, NXPE2P1, and SAR1B. Each is linked with LRPAP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRPAP1-to-partner and partner-to-LRPAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNVU1-28 grouped by LRPAP1-low versus LRPAP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRPAP1→partner) and Y-score (partner→LRPAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNVU1-28 →	+0.990	+2.957	<.001	<.001	3	2
COAD	NXPE2P1 →	+0.488	+4.596	<.001	.001	3	2
UCEC	SAR1B →	+0.514	+3.700	.003	.001	3	1
UCEC	HK3 →	+0.682	+3.721	.008	<.001	3	1
UCEC	IFT122 →	-0.614	-3.646	.002	.001	3	1
UCEC	AP1G1 →	+0.552	+3.711	.007	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 249 associations by consensus.

RNVU1-28 by LRPAP1 expression — UCEC

Explore this box plot interactively →