hydroxyacid oxidase 1Genealiases: GO · GOX · GOX1 · HAOX1
Q-omics provides the consensus-scored HAO1 profile across patient tissues and cancer cell-line models. HAO1 expression is associated with patient survival in 19 of 34 cancer types, with the highest sampling consensus in KIRP. Among the 18 cancer types available for tumor–normal comparison, HAO1 is differentially expressed in 7, with the highest sampling consensus in KIRC. Additionally, HAO1 RNA expression shows 6,569 significant pathway-activity associations, with the highest sampling consensus in LGG. Together, these results highlight KIRP, KIRC, and LGG as cancer lineages where HAO1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for HAO1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes HAO1 survival associations across molecular data types. HAO1 RNA expression shows survival associations in the most cancer types (19), followed by mutation status (3). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible HAO1 RNA expression–survival associations across cancer types. High HAO1 expression shows unfavorable associations in KIRP, KICH, THCA and LGG, but favorable associations in LIHC and BLCA. The KIRP Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRP as the clearest survival context for HAO1 RNA expression.
This table summarizes HAO1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 7, while mass-spec protein shows differences in 1. The strongest signals are observed in KIRC for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for HAO1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. HAO1 shows lower tumor expression in KIRC, LIHC, KIRP, CHOL and KICH and higher tumor expression in PRAD. The KIRC box plot shows higher HAO1 RNA expression in normal versus tumor tissue (log2 FC = −0.872, t-test p < 0.001).
This table shows molecular features associated with HAO1 in patient tissues and cancer cell lines. In patient samples, HAO1 shows the broadest associations at the RNA and protein expression levels, with LGG recurring as the lineage with the largest associated feature set. In cancer cell lines, HAO1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in PANCREAS, while CRISPR and shRNA rows add functional-dependency signals in KIDNEY and LARGE_INTESTINE.
