HAO1

Across TCGA cell cohorts, HAO1 mutation is significantly associated with the drug of many other genes, with 17 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HAO1-associated genes across cancer lineages are BMS-536924, GSK2110183B, and 123829. Each is linked with HAO1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HAO1-to-partner and partner-to-HAO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BMS-536924 grouped by HAO1-low versus HAO1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HAO1→partner) and Y-score (partner→HAO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	BMS-536924 →	+0.632	+2.649	.026	.046	3	1
LARGE_INTESTINE	GSK2110183B →	+0.802	+2.871	.004	.021	3	1
LARGE_INTESTINE	123829 →	+0.666	+2.871	.015	.021	3	1
LARGE_INTESTINE	KRAS (G12C) Inhibitor-12 →	+0.648	+2.868	.005	.022	3	1
LARGE_INTESTINE	WZ3105 →	+0.697	+2.874	.034	.021	3	1
LARGE_INTESTINE	GSK690693 →	+0.837	+2.874	<.001	.021	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

BMS-536924 by HAO1 expression — LARGE_INTESTINE

Explore this box plot interactively →