HAO1

Across TCGA pan-cancer cohorts, HAO1 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated HAO1 data layer compared with 3 for mutation status.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher HAO1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated HAO1 expression acts as an unfavorable survival marker, although some lineages such as LIHC and BLCA show a favorable association.

KIRP, LIHC, and LGG are the cancer types where HAO1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Quartile	All	0.322	0.655	<.001	61	view →
LIHC	OS	Quartile	III,IV	0.783	0.322	.001	48	view →
LGG	DFS	Median	All	0.669	0.799	<.001	45	view →
KICH	DFS	Tertile	All	0.480	0.970	.001	45	view →
THCA	OS	Tertile	All	0.952	0.997	<.001	45	view →
BLCA	OS	Tertile	All	0.564	0.381	.009	44	view →
KIRC	DFS	Quartile	II,III,IV	0.265	0.554	.017	41	view →
PAAD	DFS	Tertile	All	0.511	0.253	.004	29	view →
MESO	OS	Tertile	III,IV	0.209	0.617	.011	24	view →
CHOL	OS	Median	III,IV	0.286	1.000	.008	23	view →
TGCT	DFS	Tertile	All	0.443	0.730	.012	18	view →
SKCM	OS	Tertile	All	0.444	0.280	.013	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

HAO1–KIRP (DFS)

Open the KIRP breakdown →