HAO1

Across TCGA pan-cancer cohorts, HAO1 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of HAO1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where HAO1 RNA is repressed in tumor relative to normal tissue. In most cancer types HAO1 is over-expressed in tumor, although a few such as KIRC and LIHC show the opposite, repressed pattern.

KIRC, LIHC, and KIRP are the cancer types where HAO1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HAO1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	−0.872	<.001	11	view →
LIHC	All	All	−1.197	<.001	8	view →
KIRP	Male	II,III,IV	−1.133	<.001	8	view →
CHOL	Female	All	−8.606	<.001	5	view →
KICH	All	All	−0.444	.004	5	view →
PRAD	All	All	+0.480	.001	2	view →
BRCA	All	III,IV	−0.041	.004	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

HAO1–KIRC

Open the KIRC breakdown →