HAO1

Across TCGA patient cohorts, HAO1 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HAO1-associated genes across cancer lineages are p27_pT157, TFRC, and 14-3-3_beta. Each is linked with HAO1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HAO1-to-partner and partner-to-HAO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p27_pT157 grouped by HAO1-low versus HAO1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HAO1→partner) and Y-score (partner→HAO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p27_pT157 →	-0.053	-2.584	.049	.011	3	2
UCEC	TFRC →	+0.575	+3.700	.020	.001	3	2
UCEC	14-3-3_beta →	-0.148	-3.143	.001	.018	3	1
UCEC	EGFR_pY1068 →	-0.321	-2.321	.006	.033	3	1
UCEC	ERK2 →	+0.260	+3.321	.003	.009	3	1
UCEC	ACC1 →	+0.409	+2.820	.015	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

p27_pT157 by HAO1 expression — UCEC

Explore this box plot interactively →