HAO1

Across TCGA pan-cancer cohorts, HAO1 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated HAO1 data layer compared with 19 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher HAO1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated HAO1 expression acts as an unfavorable survival marker, although some lineages such as LUSC show a favorable association.

COAD, LGG, and LUSC are the cancer types where HAO1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	II,III,IV	0.275	0.796	.001	12	view →
LGG	OS	Median	All	0.415	0.811	.041	3	view →
LUSC	DFS	Median	All	1.000	0.752	.038	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

HAO1–COAD (OS)

Open the COAD breakdown →