HAO1

Across TCGA patient cohorts, HAO1 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,569 significant associations in total. LGG shows the largest number of these associations.

The most reproducible HAO1-associated GO terms across cancer lineages are Glycine biosynthetic process, Thioester metabolic process, and Vitamin biosynthetic process. Each is linked with HAO1 in more than 8 cancer types. Because this analysis shows association rather than direction, both HAO1-to-partner and partner-to-HAO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Glycine biosynthetic process grouped by HAO1-low versus HAO1-high in PAAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HAO1→partner) and Y-score (partner→HAO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PAAD	Glycine biosynthetic process →	-0.064	-0.510	<.001	<.001	2	9
CHOL	Thioester metabolic process →	+0.067	+5.193	<.001	<.001	3	8
STAD	Vitamin biosynthetic process →	+0.043	+0.089	<.001	<.001	2	8
READ	Regulation of very-low-density lipoprotein particle remodeling →	+0.548	+0.077	.002	.003	2	8
CHOL	Fatty acid derivative metabolic process →	+0.051	+3.835	.001	<.001	2	8
SCLC	Positive regulation of endocytosis →	+0.083	+0.040	<.001	.004	2	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,569 associations by consensus.

Glycine biosynthetic process by HAO1 expression — PAAD

Explore this box plot interactively →