HAO1

Across TCGA cell cohorts, HAO1 mutation is significantly associated with the mutation status of many other genes, with 3,023 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HAO1-associated genes across cancer lineages are CCDC40, ATP8B3, and CYP1A1. Each is linked with HAO1 in more than 2 cancer types. Because this analysis shows association rather than direction, both HAO1-to-partner and partner-to-HAO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCDC40 grouped by HAO1-low versus HAO1-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HAO1→partner) and Y-score (partner→HAO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CCDC40 →	+5.297	+5.297	.004	.004	1	3
SKIN	ATP8B3 →	+3.392	+4.718	.002	.002	1	3
SKIN	CYP1A1 →	+4.392	+4.392	.009	.009	1	3
SKIN	TP53BP2 →	+4.392	+4.392	.009	.009	1	3
LUNG_NSCLC_LUAD	ZNF648 →	+5.339	+4.772	.004	.004	1	3
SKIN	TDRD6 →	+3.655	+4.906	.001	.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,023 associations by consensus.

CCDC40 by HAO1 expression — BREAST

Explore this box plot interactively →