fizzy and cell division cycle 20 related 1Genealiases: CDC20C · CDH1 · DEE109 · FZR · FZR2 · HCDH
Q-omics provides the consensus-scored FZR1 profile across patient tissues and cancer cell-line models. FZR1 expression is associated with patient survival in 22 of 34 cancer types, with the highest sampling consensus in UCEC. Among the 18 cancer types available for tumor–normal comparison, FZR1 is differentially expressed in 14, with the highest sampling consensus in KIRC. Additionally, FZR1 RNA expression shows 19,050 significant gene co-expression associations, with the highest sampling consensus in ACC. Together, these results highlight UCEC, KIRC, and ACC as cancer lineages where FZR1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for FZR1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes FZR1 survival associations across molecular data types. FZR1 RNA expression shows survival associations in the most cancer types (22), followed by mutation status (7) and mass-spec protein abundance (8). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible FZR1 RNA expression–survival associations across cancer types. High FZR1 expression shows unfavorable associations in MESO and KICH, but favorable associations in UCEC, CESC, UVM and THYM. The UCEC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p = .001). Together, the overview and detailed table identify UCEC as the clearest survival context for FZR1 RNA expression.
This table summarizes FZR1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 14, while mass-spec protein shows differences in 8. The strongest signals are observed in KIRC for RNA and LSCC for protein.
This table ranks reproducible tumor–normal expression differences for FZR1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. FZR1 shows lower tumor expression in THCA and higher tumor expression in KIRC, HNSC, COAD, LIHC and STAD. The KIRC box plot shows higher FZR1 RNA expression in tumor versus normal tissue (log2 FC = +0.502, t-test p < 0.001).
This table shows molecular features associated with FZR1 in patient tissues and cancer cell lines. In patient samples, FZR1 shows the broadest associations at the RNA and protein expression levels, with ACC recurring as the lineage with the largest associated feature set. In cancer cell lines, FZR1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in SOFT_TISSUE, while CRISPR and shRNA rows add functional-dependency signals in STOMACH and BLOOD_Leukemia.
