FZR1

Across TCGA patient cohorts, FZR1 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FZR1-associated genes across cancer lineages are ATM, Src_pY527, and Caspase-7-cleavedD198. Each is linked with FZR1 in more than 3 cancer types. Because this analysis shows association rather than direction, both FZR1-to-partner and partner-to-FZR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by FZR1-low versus FZR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FZR1→partner) and Y-score (partner→FZR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.603	-2.087	<.001	.005	3	4
UCEC	Src_pY527 →	-0.529	-3.321	.001	.009	3	2
UCEC	Caspase-7-cleavedD198 →	+0.935	+3.827	<.001	<.001	3	2
UCEC	DJ-1 →	+0.175	+3.183	.006	.009	3	2
UCEC	EGFR_pY1068 →	-0.366	-4.087	<.001	<.001	3	1
UCEC	eIF4E →	+0.164	+3.472	.042	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

ATM by FZR1 expression — UCEC

Explore this box plot interactively →