FZR1

Across TCGA pan-cancer cohorts, FZR1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated FZR1 data layer compared with 7 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher FZR1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated FZR1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and CESC show a favorable association.

UCEC, MESO, and CESC are the cancer types where FZR1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	0.885	0.761	.001	92	view →
MESO	OS	Quartile	All	0.372	0.702	<.001	80	view →
CESC	DFS	Quartile	All	0.842	0.633	.002	34	view →
UVM	OS	Quartile	All	1.000	0.679	.007	31	view →
THYM	OS	Median	II,III,IV	1.000	0.884	.008	28	view →
KICH	DFS	Median	III,IV	0.373	1.000	.008	25	view →
LUAD	DFS	Tertile	II,III,IV	0.537	0.765	.011	25	view →
LIHC	OS	Median	II,III,IV	0.483	0.730	.001	24	view →
ACC	DFS	Quartile	All	0.236	0.707	.002	23	view →
KIRC	DFS	Tertile	All	0.784	0.564	.010	14	view →
SKCM	OS	Tertile	All	0.262	0.537	.004	13	view →
SARC	OS	Quartile	All	0.647	0.916	<.001	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

FZR1–UCEC (DFS)

Open the UCEC breakdown →