FZR1

Across TCGA pan-cancer cohorts, FZR1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of FZR1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where FZR1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FZR1 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

KIRC, HNSC, and COAD are the cancer types where FZR1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FZR1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+0.502	<.001	11	view →
HNSC	Male	IV	+1.055	<.001	10	view →
COAD	Female	All	+0.803	<.001	10	view →
THCA	All	II,III,IV	−0.318	<.001	10	view →
LIHC	Female	II,III,IV	+1.104	<.001	8	view →
STAD	All	II,III,IV	+0.778	<.001	8	view →
LUSC	Female	All	+0.741	<.001	7	view →
READ	All	III,IV	+0.844	.005	4	view →
BRCA	All	All	+0.265	.002	4	view →
CHOL	Male	All	+1.620	<.001	3	view →
BLCA	All	All	+0.371	.013	3	view →
KIRP	All	IV	+0.847	.031	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

FZR1–KIRC

Open the KIRC breakdown →