FZR1

Across TCGA cell cohorts, FZR1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,961 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FZR1-associated GO terms across cancer lineages are Positive regulation of anaphase-promoting complex-dependent catabolic process, Negative regulation of protein localization to chromatin, and Regulation of anaphase-promoting complex-dependent catabolic process. Each is linked with FZR1 in more than 19 cancer types. Because this analysis shows association rather than direction, both FZR1-to-partner and partner-to-FZR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of anaphase-promoting complex-dependent catabolic process grouped by FZR1-low versus FZR1-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FZR1→partner) and Y-score (partner→FZR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Positive regulation of anaphase-promoting complex-dependent catabolic process →	+0.173	+0.896	<.001	<.001	3	20
LUNG_NSCLC_LUSC	Negative regulation of protein localization to chromatin →	+0.203	+1.155	.001	.003	3	19
BONE	Regulation of anaphase-promoting complex-dependent catabolic process →	+0.155	+0.926	<.001	<.001	3	19
BONE	Positive regulation of mitotic cytokinesis →	+0.144	+0.784	.004	.001	3	18
SKIN	Positive regulation of cytokinesis →	+0.099	+0.764	<.001	<.001	3	18
STOMACH	Regulation of protein localization to chromatin →	+0.138	+1.092	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,961 associations by consensus.

Positive regulation of anaphase-promoting complex-dependent catabolic process by FZR1 expression — LUNG_SCLC

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