FZR1

Across TCGA pan-cancer cohorts, FZR1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated FZR1 data layer compared with 22 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher FZR1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated FZR1 expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

CCRCC, PDAC, and LUAD are the cancer types where FZR1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	III,IV	0.105	0.755	.001	47	view →
PDAC	OS	Quartile	II,III,IV	0.228	0.765	.009	12	view →
LUAD	DFS	Median	III,IV	0.681	0.369	.049	3	view →
GBM	OS	Quartile	All	0.393	0.576	.030	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

FZR1–CCRCC (OS)

Open the CCRCC breakdown →