FZR1

Across TCGA patient cohorts, FZR1 protein abundance is significantly associated with the RNA expression of many other genes, with 5,663 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible FZR1-associated genes across cancer lineages are ARHGAP21, G3BP1, and GPR180. Each is linked with FZR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FZR1-to-partner and partner-to-FZR1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, FZR1 versus ARHGAP21 in BRCA, with a Pearson correlation of 0.36.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FZR1→partner) and Y-score (partner→FZR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ARHGAP21 →	+0.636	+0.267	<.001	<.001	3	2
LSCC	G3BP1 →	+0.368	+0.179	.002	.004	3	2
BRCA	GPR180 →	+0.321	+0.163	.005	.003	3	2
BRCA	STK38L →	+0.842	+0.278	<.001	.001	3	2
COAD	MBLAC2 →	+0.419	+1.346	.005	.006	3	2
COAD	EIF3CL →	+0.920	+1.937	.002	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,663 associations by consensus.

FZR1 vs ARHGAP21 — BRCA

Explore this scatter interactively →