FZR1

Across TCGA cell cohorts, FZR1 mutation is significantly associated with the RNA expression of many other genes, with 60 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FZR1-associated genes across cancer lineages are LCE1B, ADH1A, and AGXT2. Each is linked with FZR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FZR1-to-partner and partner-to-FZR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LCE1B grouped by FZR1-low versus FZR1-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FZR1→partner) and Y-score (partner→FZR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	LCE1B →	+0.024	+4.491	.001	.003	3	2
LARGE_INTESTINE	ADH1A →	+0.087	+2.920	.006	.001	3	2
PANCREAS	AGXT2 →	+0.062	+5.139	<.001	<.001	3	1
PANCREAS	SHISAL2B →	+0.169	+4.011	<.001	.009	3	1
PANCREAS	NAT8B →	+0.145	+4.011	<.001	.009	3	1
PANCREAS	SCYGR2 →	+0.099	+4.614	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 60 associations by consensus.

LCE1B by FZR1 expression — PANCREAS

Explore this box plot interactively →