family with sequence similarity 76 member AGenealiases: []
Q-omics provides the consensus-scored FAM76A profile across patient tissues and cancer cell-line models. FAM76A expression is associated with patient survival in 24 of 34 cancer types, with the highest sampling consensus in LUAD. Among the 18 cancer types available for tumor–normal comparison, FAM76A is differentially expressed in 12, with the highest sampling consensus in KICH. Additionally, FAM76A RNA expression shows 19,790 significant gene co-expression associations, with the highest sampling consensus in ACC. Together, these results highlight LUAD, KICH, and ACC as cancer lineages where FAM76A shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for FAM76A — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes FAM76A survival associations across molecular data types. FAM76A RNA expression shows survival associations in the most cancer types (24), followed by mutation status (3) and mass-spec protein abundance (6). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible FAM76A RNA expression–survival associations across cancer types. High FAM76A expression shows unfavorable associations in ACC, LGG and LIHC, but favorable associations in LUAD, KIRC and UCS. The LUAD Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify LUAD as the clearest survival context for FAM76A RNA expression.
This table summarizes FAM76A tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 12, while mass-spec protein shows differences in 6. The strongest signals are observed in KICH for RNA and LUAD for protein.
This table ranks reproducible tumor–normal expression differences for FAM76A. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. FAM76A shows lower tumor expression in KICH, THCA, LUAD and KIRP and higher tumor expression in LIHC and HNSC. The KICH box plot shows higher FAM76A RNA expression in normal versus tumor tissue (log2 FC = −1.151, t-test p < 0.001).
This table shows molecular features associated with FAM76A in patient tissues and cancer cell lines. In patient samples, FAM76A shows the broadest associations at the RNA and protein expression levels, with ACC recurring as the lineage with the largest associated feature set. In cancer cell lines, FAM76A RNA and mutation anchors are most strongly linked to RNA-expression features, especially in CNS, while CRISPR and shRNA rows add functional-dependency signals in BREAST and BLOOD_Leukemia.
