FAM76A

Across TCGA pan-cancer cohorts, FAM76A RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated FAM76A data layer compared with 3 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher FAM76A RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated FAM76A expression acts as an unfavorable survival marker, although some lineages such as LUAD and KIRC show a favorable association.

LUAD, ACC, and KIRC are the cancer types where FAM76A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	All	0.844	0.713	<.001	95	view →
ACC	DFS	Median	All	0.245	0.656	<.001	92	view →
KIRC	OS	Median	All	0.852	0.758	<.001	75	view →
LGG	DFS	Median	All	0.669	0.804	<.001	49	view →
LIHC	DFS	Median	All	0.465	0.619	<.001	35	view →
UCS	DFS	Tertile	IV	0.942	0.363	.024	24	view →
UCEC	OS	Tertile	III,IV	0.908	0.753	.004	24	view →
SKCM	DFS	Median	II,III,IV	0.294	0.154	.001	23	view →
ESCA	OS	Tertile	All	0.600	0.377	.008	15	view →
KIRP	OS	Median	All	0.923	0.841	.016	12	view →
OV	DFS	Median	III,IV	0.123	0.182	.026	12	view →
BLCA	OS	Median	III,IV	0.746	0.613	.022	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

FAM76A–LUAD (DFS)

Open the LUAD breakdown →