FAM76A

Across TCGA pan-cancer cohorts, FAM76A RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of FAM76A’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where FAM76A RNA is repressed in tumor relative to normal tissue. In most cancer types FAM76A is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, THCA, and LUAD are the cancer types where FAM76A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FAM76A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	III,IV	−1.151	<.001	11	view →
THCA	Male	III,IV	−0.854	<.001	10	view →
LUAD	Female	III,IV	−0.829	<.001	9	view →
LIHC	All	II,III,IV	+0.488	<.001	7	view →
HNSC	All	III,IV	+0.314	.009	7	view →
KIRP	All	All	−0.428	<.001	6	view →
BRCA	Female	All	−0.346	<.001	6	view →
LUSC	All	II,III,IV	−0.523	<.001	5	view →
CHOL	Male	All	+1.158	<.001	3	view →
UCEC	All	All	−0.485	.002	2	view →
PRAD	All	All	−0.399	<.001	2	view →
KIRC	All	II,III,IV	−0.237	.020	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

FAM76A–KICH

Open the KICH breakdown →