FAM76A

Across TCGA patient cohorts, FAM76A mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM76A-associated genes across cancer lineages are Notch1, STAT3_pY705, and VHL. Each is linked with FAM76A in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM76A-to-partner and partner-to-FAM76A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by FAM76A-low versus FAM76A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM76A→partner) and Y-score (partner→FAM76A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.222	+3.009	.006	.019	3	1
UCEC	STAT3_pY705 →	-0.512	-3.000	<.001	.037	3	1
UCEC	VHL →	-1.369	-3.000	<.001	.036	3	1
UCEC	ATM →	-0.802	-3.000	.002	.037	3	1
UCEC	MEK1 →	+0.594	+3.000	.004	.037	2	1
UCEC	TFRC →	+0.755	+3.000	.013	.037	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Notch1 by FAM76A expression — UCEC

Explore this box plot interactively →