FAM76A

Across TCGA pan-cancer cohorts, FAM76A mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated FAM76A data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher FAM76A mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated FAM76A expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

HNSC, LUAD, and PDAC are the cancer types where FAM76A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	0.662	0.894	<.001	34	view →
LUAD	DFS	Median	All	1.000	0.640	.001	21	view →
PDAC	OS	Tertile	All	0.984	0.594	<.001	15	view →
UCEC	DFS	Median	All	1.000	0.936	.023	8	view →
LSCC	OS	Tertile	II,III,IV	0.900	0.610	.029	5	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

FAM76A–HNSC (DFS)

Open the HNSC breakdown →