FAM76A

Across TCGA patient cohorts, FAM76A mutation is significantly associated with the RNA expression of many other genes, with 1,053 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM76A-associated genes across cancer lineages are MIR1258, SAP18P1, and SRSF3P2. Each is linked with FAM76A in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM76A-to-partner and partner-to-FAM76A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR1258 grouped by FAM76A-low versus FAM76A-high in KIRC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM76A→partner) and Y-score (partner→FAM76A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIRC	MIR1258 →	+0.308	+8.025	<.001	.007	3	2
SKCM	SAP18P1 →	+0.054	+4.328	<.001	.007	3	2
BLCA	SRSF3P2 →	+0.138	+3.735	.001	.005	3	2
UCEC	TEX43 →	+0.492	+3.003	<.001	<.001	3	2
UCEC	RNU1-17P →	+0.203	+2.765	.003	.005	3	2
UCEC	RN7SL472P →	+0.451	+2.330	.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,053 associations by consensus.

MIR1258 by FAM76A expression — KIRC

Explore this box plot interactively →