FAM76A

Across TCGA pan-cancer cohorts, FAM76A mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of FAM76A’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where FAM76A mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types FAM76A is over-expressed in tumor, although a few such as CCRCC and PDAC show the opposite, repressed pattern.

LUAD, HNSC, and LSCC are the cancer types where FAM76A tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FAM76A mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	III,IV	+0.303	<.001	9	view →
HNSC	All	III,IV	+0.217	<.001	8	view →
LSCC	Male	All	+0.310	<.001	6	view →
CCRCC	Female	All	−0.295	<.001	4	view →
PDAC	All	All	−0.208	.024	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

FAM76A–LUAD

Open the LUAD breakdown →