Q-omics provides the consensus-scored CRY2 profile across patient tissues and cancer cell-line models. CRY2 expression is associated with patient survival in 28 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, CRY2 is differentially expressed in 16, with the highest sampling consensus in THCA. Additionally, CRY2 RNA expression shows 20,693 significant gene co-expression associations, with the highest sampling consensus in ACC. Together, these results highlight KIRC, THCA, and ACC as cancer lineages where CRY2 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for CRY2 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes CRY2 survival associations across molecular data types. CRY2 RNA expression shows survival associations in the most cancer types (28), followed by mutation status (4) and mass-spec protein abundance (5). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible CRY2 RNA expression–survival associations across cancer types. High CRY2 expression shows favorable associations in KIRC, KIRP, UVM, LUAD, LGG and MESO. The KIRC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for CRY2 RNA expression.
This table summarizes CRY2 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 16, while mass-spec protein shows differences in 4. The strongest signals are observed in THCA for RNA and LSCC for protein.
This table ranks reproducible tumor–normal expression differences for CRY2. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. CRY2 shows lower tumor expression in THCA, BLCA, LUAD, LUSC, HNSC and COAD. The THCA box plot shows higher CRY2 RNA expression in normal versus tumor tissue (log2 FC = −1.729, t-test p < 0.001).
This table shows molecular features associated with CRY2 in patient tissues and cancer cell lines. In patient samples, CRY2 shows the broadest associations at the RNA and protein expression levels, with ACC recurring as the lineage with the largest associated feature set. In cancer cell lines, CRY2 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LUNG_NSCLC_LUSC, while CRISPR and shRNA rows add functional-dependency signals in BLOOD_Lymphoma and BLOOD_Leukemia.
