CRY2

Across TCGA patient cohorts, CRY2 mutation is significantly associated with the RNA expression of many other genes, with 3,496 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CRY2-associated genes across cancer lineages are MIR1263, KRT8P6, and RNU7-81P. Each is linked with CRY2 in more than 2 cancer types. Because this analysis shows association rather than direction, both CRY2-to-partner and partner-to-CRY2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR1263 grouped by CRY2-low versus CRY2-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRY2→partner) and Y-score (partner→CRY2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR1263 →	+0.183	+7.471	<.001	.008	3	3
COAD	KRT8P6 →	+0.111	+2.984	<.001	.009	3	3
COAD	RNU7-81P →	+0.290	+4.595	<.001	.004	3	3
UCEC	MIGA1 →	+0.406	+3.742	.003	<.001	3	2
UCEC	PRMT3 →	+0.437	+2.839	.003	.001	3	2
UCEC	HEXIM1 →	+0.434	+1.773	.004	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,496 associations by consensus.

MIR1263 by CRY2 expression — BRCA

Explore this box plot interactively →